NAD⁺ molecule reverses memory loss in Alzheimer's models
Boosting NAD⁺ levels restores memory in Alzheimer's models by fixing RNA splicing errors, offering a new therapeutic target.
Why it matters
- NAD⁺ corrects RNA splicing errors, crucial for neuron health.
- Offers a new pathway for Alzheimer's treatment.
By the numbers
- EVA1C protein levels significantly reduced in AD patients' brain samples.
- Study used worms and mice models.
The big picture
- NAD⁺ levels decline with age and are linked to better health.
- Targeting the NAD⁺–EVA1C pathway could delay cognitive decline.
What they're saying
- Public interest is high due to personal concerns about Alzheimer's.
- Some skepticism about practical applications.
- Recognized as progress but not a complete treatment yet.
Caveats
- Study conducted in animal models; human trials needed.
- Long way from being a full treatment.
What’s next
- Further research on NAD⁺ supplementation and its effects in humans.
- Potential combination treatments to enhance RNA splicing.