New CRISPR method reactivates silenced genes
New CRISPR technique removes methyl groups to switch genes back on, confirming methylation's role in gene silencing.
Why it matters
- Confirms methylation directly silences genes.
- Safer CRISPR therapy for genetic diseases like Sickle Cell.
By the numbers
- Lab study on human cells.
- Third-generation CRISPR: epigenetic editing.
The big picture
- Epigenetic editing could treat genetic diseases without DNA cuts, reducing cancer risk.
What they're saying
- Breakthrough in targeted demethylation noted by commenters.
- Potential for broader genetic disease treatments highlighted.
Caveats
- Early-stage research; animal and clinical trials next.
What’s next
- Testing in animal models and clinical trials.