New drug shows promise for treating alcohol use disorder
Study finds tolcapone boosts brain activity, improves control, and reduces drinking.
Why it matters
- AUD is a significant health issue with limited treatment options.
- New approach targets brain circuits involved in self-control.
By the numbers
- 64 participants with AUD were involved in the study.
- Tolcapone increased prefrontal cortex activity and reduced alcohol consumption.
The big picture
- Medications increasing prefrontal dopamine could help treat AUD.
- Targets impaired inhibitory control, a key issue in AUD.
What they're saying
- Interest in evaluating tolcapone for ADHD.
- Concerns about potential liver toxicity.
Caveats
- Small-scale clinical trial; larger studies needed.
- Potential side effects like liver toxicity.
What’s next
- Further research to confirm findings and explore other potential applications.