New genetic targets for anti-aging discovered.
Scientists mapped the most detailed genetic blueprint of frailty, uncovering 371 new genetic targets for anti-aging therapies.
Why it matters
- Frailty affects 40% of people aged 65+, increasing risks of hospitalization, disability, and death.
- New genetic insights could lead to targeted anti-aging therapies.
By the numbers
- Study analyzed DNA of over 400,000 people.
- Identified 408 genetic loci linked to frailty, with 371 being newly discovered.
The big picture
- Frailty is complex and involves multiple biological pathways.
- Findings support the idea that frailty is a treatable biological condition, not an inevitable part of aging.
What they're saying
- Dr. Kenneth Rockwood: "Aging is not just one thing. There are many ways to be frail."
- Researchers suggest broadening clinical measurements of frailty to include new subtypes.
Caveats
- Frailty is highly polygenic, meaning no single gene is responsible; treatments will need to be personalized.
- More research needed to develop effective interventions based on these genetic targets.
What’s next
- Next steps include figuring out how to treat the underlying biology identified in the study.
- Potential for personalized treatments targeting specific biological pathways.