Single fecal transplant in teens shows long-term metabolic benefits
Single FMT in obese teens led to long-term metabolic benefits.
Why it matters
- A single fecal microbiota transplant (FMT) in obese teens delivered long-lasting metabolic benefits.
- These benefits include shrinking waistlines, reducing body fat, inflammation, and lowering heart disease risk markers.
By the numbers
- 87 adolescents aged 14-18 participated.
- Follow-up after 4 years with 55 participants (63% of original group).
- Treatment group had 10 cm (3.9 in) smaller waistlines and 5% less body fat.
The big picture
- The study highlights the potential of FMT in treating obesity and related metabolic conditions.
- Long-term changes in gut bacteria and viruses were observed, suggesting sustained effects.
- Research paves the way for next-generation probiotics targeting specific conditions.
What they're saying
- Comments reflect fascination with the gut microbiome's impact on health.
- Questions about the mechanism of action, such as GLP 1 or GIP stimulation.
Caveats
- No significant differences in weight and BMI between FMT and placebo groups.
- No major changes in blood sugar control or most other cholesterol and lipid markers.
- Follow-up included only 63% of original participants.
What’s next
- Researchers aim to develop a super mix of bacteria to prevent or moderate metabolic syndrome.
- Further studies needed to confirm and expand on these findings.